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pentobarbital will reduce the extent or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, deficiency of efficacy or, probably, improvement of the withdrawal syndrome in a very patient that has created Bodily dependence to fentanyl.

pentobarbital will reduce the level or impact of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Potent CYP3A4 inducers are predicted to result in substantial decreases in sildenafil plasma amounts

Contraindicated (one)pentobarbital will lower the level or impact of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Contraindicated (1)pentobarbital will reduce the level or impact of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with potent CYP3A4 inducers is just not advisable

pentobarbital will lower the level or impact of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.

pentobarbital will reduce the extent or impact of ketoconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unfamiliar.

pentobarbital will reduce the level or result of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Powerful or reasonable CYP3A4 inducers may boost amount of diazepam elimination; therefore, efficacy of diazepam could possibly be lessened.

pentobarbital will minimize the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

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Contraindicated (one)pentobarbital will minimize the extent or influence of lumacaftor/ivacaftor by influencing hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will reduce the level or influence more info of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers may lead to lessened serum concentrations and loss of antimalarial efficacy

pentobarbital will decrease the extent or impact of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; steer clear of use in sufferers that are chronically utilizing a robust CYP3A4 inducer

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pentobarbital will lower the extent or influence of alosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.