pentobarbital will reduce the extent or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, deficiency of efficacy or, probably, improvement of the withdrawal syndrome in a very pat… Read More